The Pioglitazone microcapsules were formulated to extend the hypoglycemic effect up to a period of 12hours. The pioglitazone microcapsules were formulated by employing orifice ionic gelation technique. The effect of various process variables such as polymer concentration, core : coat ratio, curing reagent, curing time, concentration of curing reagent, volume of curing reagent on the entrapment effeciency and drug release rate was studied. The optimized formulation was selected based on the entrapment effeciency and drug release rate. The optimized formulation of pioglitazone microcapsules were subjected to the hypoglycemic activity in healthy albino rabbits [n=5]. The blood glucose levels were measured and then percentage glucose reduction was calculated. The data was treated statistically. Compared the mean blood glucose levels observed from poglitazone and its microcapsules. The hypoglycemic activity of pure drug was observed maximum at 6th hour and the hypoglycemic activity of its microcapsules was observed maximun at 8th hour and it was extended up to 10th hour.
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